Collects Spider-Man/Deadpool #9-10, 13-14, 17-18.

Take a little bit of Spidey and a touch of Deadpool, take away the Y chromosomes, blend it all together and what do you get? Peter Parker and Wade Wilson's worst nightmare -the murderous, mixed-up miss named Itsy Bitsy! The "daughter" of our two heroes is stronger than them, faster than them and has seriously creepy daddy issues - but what crazed mind could have conceived of her in the first place? As the body count begins to rise, somehow Spider-Man and Deadpool must work together to take down Itsy-Bitsy -and the person who has been pulling their strings from the start! But how is a trip to Weirdworld going to help wash that spider out? It's the most disturbing Spidey/Deadpool story yet!